Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
Second-half goals from substitutes Fred and Anthony Elanga earned Manchester United a 4-2 victory over Leeds United in a thriller at Elland Road in the Premier League on Sunday.
IMAGES from the Premier League matches played on Wednesday.
Erik ten Hag's side will face Championship (second-tier) outfit Coventry City in the semis after they upset Wolverhampton Wanderers 3-2 on Saturday.
Man United get injury boost ahead of Liverpool FA Cup clash
They have one of the most exciting squads around, full of proven matchwinners to take the burden off Ronaldo.
Manchester United got their pre-season off to a flying start with a 4-0 rout of rivals Liverpool in Thailand on Tuesday, giving new manager Erik ten Hag a big boost in his first match in charge.
IMAGES from the English Premier League matches played on Sunday.
Manchester City inched closer to their treble as they downed Manchester United in the FA Cup final on Saturday.
'The boys will be pleased not to lose but also definitely not happy we didn't win.'
FIFA WC PIX: Ghana vs Portugal
Man United out of Europe after 1-0 home loss to Bayern Munich
Ronaldo said that he is not worried about how his actions will impact the squad
Manchester United's Alejandro Garnacho scored with a magical overhead kick in the third minute to send the visitors on their way to a 3-0 victory over an Everton team already reeling in their first Premier League game after being docked 10 points.
IMAGES from the Premier League matches played across England, on Sunday.
BBC pundit Chris Sutton said United had "hit rock bottom" while his former strike partner Alan Shearer put down the debacle to years of mismanagement at Old Trafford.
Bruno Fernandes struck from the penalty spot in the ninth minute of stoppage time to give Manchester United victory at Brighton & Hove Albion in the Premier League on Saturday after an incredible finale.
Phil Foden kept Manchester City's Premier League title challenge on track with a superb second-half double as his side hit back to clinch a 3-1 home victory over Manchester United on Sunday.
Manchester United's Champions League qualification hopes suffered a blow after an equaliser deep in stoppage time from Michael Obafemi earned Southampton a 2-2 draw in the Premier League at Old Trafford on Monday.
Guedes, 22, nutmegged Matthijs de Ligt, exchanged passes with Bernando Silva and then beat goalkeeper Jasper Cillessen with a shot from the edge of the area on the hour for his fourth international goal in 17 appearances.
Manchester City chalked up yet another victory to maintain their stranglehold of the Premier League title race but pursuers Manchester United and Leicester City both secured important wins to enhance their top-four bids on Sunday.
European champions Spain claimed a place in the Nations League quarter-finals with a 3-0 home win over Serbia.
Manchester United took a big step towards the Europa League quarter-finals by thrashing Austrian side LASK Linz 5-0 on Thursday in their last 16 first-leg tie at an empty Linzer Stadium due to the coronavirus pandemic.
Images from Saturday's action in the English Premier League.
City boss Pep Guardiola was named Manager of the Season for a third time.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.
"Everything will not be complete if we don't win the Champions League now. We have done some incredible seasons."
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
Manchester United forward Cristiano Ronaldo will leave with immediate effect, the English Premier League team said on Tuesday, marking a bitter end to the Portugal captain's second spell at Old Trafford after he said he felt betrayed by the club.
IMAGES from the Premier League matches played on Saturday.
A summary of Saturday's action in the UEFA Nations League.
Images from the Premier League matches played on Thursday
Manchester United suffered their first defeat under interim manager Ralf Rangnick, falling to a 1-0 loss at home to Wolverhampton Wanderers in the English Premier League on Monday.
Barcelona have reached the semis only once since winning the Champions League in 2014-15.
Morocco will no doubt revel in another opportunity to thrive as underdogs
Portugal coach Fernando Santos took the brave call to bench Cristiano Ronaldo and was rewarded with an artful display from his side as they set up a last-eight clash with Morocco
Manchester United climbed to third place in their quest for a berth in next season's Champions League.
Manchester United fought back to overpower West Ham United 3-1 and reach the FA Cup quarter-finals.
Ronaldo answered his critics five minutes after halftime with a superb finish
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